Research Thursday: Breastfeeding in infancy protects against the development of Crohn's disease and ulcerative colitis
June 23, 2022
Here is the citation
Xu L, Lochhead Y, Ko B et al. Systematic review with meta-analysis: Breastfeeding and the risk of Crohn’s disease and ulcerative colitis. Alimentary Pharmacology & Therapeutics. 2017 September;46(9):780-789.
Here is the PubMed link. This is a free access article. PubMed link
Here is what I think.
Despite being on the older side (published in 2017) I like this study for several reasons. First, because it is a systematic review with a meta-analysis - so strong research. Look at the numbers: 7536 individuals with Crohn’s disease, 7353 with ulcerative colitis and 330,222 controls. This study also provides a great, succinct teaching point: “Breastfeeding in infancy protects against the development of Crohn’s disease and ulcerative colitis.”
Here is the abstract.
Background: Breastfeeding is a modifiable factor that may influence development of inflammatory bowel diseases. However, literature on this has been inconsistent and not accounted for heterogeneity in populations and exposure.
Aim: To conduct a meta-analysis to examine the association between breastfeeding in infancy and risk of Crohn's disease (CD) and ulcerative colitis (UC).
Methods: A systematic search of Medline/PubMed and Embase was performed for full text, English-language literature through November 2016. Studies were included if they described breastfeeding in infancy in patients with CD or UC, and healthy controls. Data were pooled using a random effects model for analysis.
Results: A total of 35 studies were included in the final analysis, comprising 7536 individuals with CD, 7353 with UC and 330 222 controls. Ever being breastfed was associated with a lower risk of CD (OR 0.71, 95% CI 0.59-0.85) and UC (OR 0.78, 95% CI 0.67-0.91). While this inverse association was observed in all ethnicity groups, the magnitude of protection was significantly greater among Asians (OR 0.31, 95% CI 0.20-0.48) compared to Caucasians (OR 0.78, 95% CI 0.66-0.93; P = .0001) in CD. Breastfeeding duration showed a dose-dependent association, with strongest decrease in risk when breastfed for at least 12 months for CD (OR 0.20, 95% CI 0.08-0.50) and UC (OR 0.21, 95% CI 0.10-0.43) as compared to 3 or 6 months.
Conclusion: Breastfeeding in infancy protects against the development of CD and ulcerative colitis.